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The sentencing of notorious Mexican dose master Osiel C?rdenas Guill?n this hebdomad in a Houston tribunal underscores a longstanding battle in the Mexican dose war: Cartels cover to thrive on the Mexico-U.S. delimitation level below a law enforcement scheme where top leadership are captured and sent to the U.S.

Mr. C?rdenas, leader of Mexico’s Gulf Cartel, was sentenced to 25 years in prison nether a supplication hand Wednesday, about vii years later his initial get in Mexico. The Gulf Cartel, one of Mexico’s largest, has black-market thousands of pounds of cocain and marihuana into the U.S. primarily done South Texas, according to U.S. regime.

Review key events in the competitiveness to gaolbreak the clutch of Mexico’s dose cartels.

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Mr. C?rdenas pleaded shamefaced to pentad counts that included money laundering, dose dispersion and the attempted mangle of federal agents. He likewise agreed to confiscate $50 gazillion in assets. His sentencing was held in mystical Wednesday in Houston, where the federal judge based in Brownsville stirred the earshot. That agreement was made due to the potential “impendent peril” to e’eryone at the audition, according to the court copy uncertain Thursday.

“I tone that [in] this clip that I get dog-tired in jail, I let reflected and I’ve realised the…ill deportment that I was maintaining, and truthfully, I am rueful,” Mr. C?rdenas aforesaid, according to the copy.

Few difference that Mr. C?rdenas’s 2003 pinch pronounced a major triumph for the Mexican authorities—and one of its soonest—in assaultive dose cartels by capturing top leadership. He was extradited to the U.S. in 2007 on with 14 otc suspected dose lords, a breakage with distinctive Mexican insurance.

But s of the U.S. mete, Mr. C?rdenas’s imperium continues to maneuver without him. Overall dose dealings from Mexico to U.S. has adult, experts say. Far from snuffing out operations, his sentencing bequeath just leave-taking existent Mexican dose lords “nerve-racking to get a meliorate bargaining situation,” says Alberto Islas, a Mexico City certificate adviser.

A erstwhile car-mechanic in the northerly commonwealth of Tamaulipas, Mr. C?rdenas rosiness done the ranks of the Gulf Cartel done his ties to Juan Garc?a Abrego, so the organisation’s leader. Mr. Garc?a was afterward arrested and Mr. C?rdenas took mastery of the establishment.

Mr. C?rdenas became fabled when he scored a major takeover against the governance: The enlisting of around 30 members of the Airborne Special Forces Groups, an elect Mexican army squadron trained in the U.S. The defectors became known as Los Zetas, the extremely feared enforcement annexe of the Gulf Cartel known for its military-like assassinations that included the use of surface-to-air missiles and modernistic wiretapping equipment.

Mr. C?rdenas’s pinch, far from stanching the dose job at the molding, may suffer helped to produce yet another trust in Mexico’s dose wars. Since his halt, Los Zetas bear gradually burst off into a grouping of their own, delving not just in dose trafficking but the crusade of fake product and the snatch on the Central American migrants.

Drug experts say that Mr. Cardenas has been cooperating with regime since his check in 2007, devising it improbable that any new data testament aerofoil in the weeks pursual the sentencing. George W. Grayson, a prof at the College of William Mary who has scripted roughly the cartels says he suspects Mr. Cardenas “gave entropy more in esteem to the construction and the modus operandi of the trust,” quite than “designation names.”

—Leslie Eaton contributed to this clause.

Write to Nicholas Casey at nicholas.casey@wsj.com